Pharmacokinetic drug dosing information is provided for the following drugs: acyclovir intravenous dosing, aminoglycosides, digoxin, lithium, phenobarbital, phenytoin, and vancomycin.
Bayesian pharmacokinetic dosing calculators, dosing charts, and graphic dosing tools are available for aminoglycosides (amikacin, gentamicin, and tobramycin), digoxin, lithium, phenobarbital, phenytoin, theophylline, and vancomycin. Bayesian dosing tools are available as Excel Spreadsheets which may be downloaded. These are located on the specific drug's page and in the links below. The purpose of these tools is educational and to prevent dosing errors due to hand calculations, standardize the process, and decrease the time required to calculate an appropriate regimen. Please review the information on the drug's page before using the dosing tools. Other drug dosing calculators will be added as time permits. If there is a particular dosing tool you would like created that is not available please email a request.
The dosing tools (charts, graphics, and calculators) use standard non-abbreviated pharmacokinetic dosing equations for a one-compartment open model. The equations are provided on the Basic Pharmacokinetic Principles and One-Compartment Model Equations page. Simplified dosing equations are included below for those who wish to do hand calculations. The calculators determine the patient's creatinine clearance, dosing weight, drug clearance, volume of distribution, dose per kg of dosing weight, loading dose, and appropriate maintenance regimen. The user may then input the desired dosing regimen. Their advantage is the lack of hand calculations and ease of use. The calculators may be used to analyze serum levels. The graphic tools are non-Bayesian and are faster and easier to use than traditional programs or calculators when a single serum level is being analyzed. Ideally one can determine the initial regimen with the dosing calculator and then use the graphic tools for further dosage adjustments when once-daily dosing of aminoglycosides.
Two-compartment model equations and simulations for vancomycin with comparison to a one-compartment model are located on the vancomycin two-compartment model page. Vancomycin medication usage evaluations for a one-compartment model, two-compartment model, and hemodialysis dosing are located on the vancomycin page.
An Adult Infusion Rate Calculator and Adult Drip Rate Charts are available for vasoactive drugs, anticoagulants, and other medications (amiodarone, argatroban, bivalirudin, diltiazem, dopamine, dobutamine, epinephrine, esmolol, fenoldopam, heparin, integrilin, insulin, isoproterenol, labetalol, milrinone, nesiritide, nitroglycerine, nitroprusside, norepinephrine, phenylephrine, procainamide, and propofol). The purpose of the infusion rate dosing tools are to prevent medication errors, standardized concentrations, and assist the nurse taking care of a patient.
This site is developed and maintained for educational use. No warranties are expressed or implied.
If you have questions or suggestions concerning the dosing tools please contact Marshall Pierce PharmD.
Please help support the development and maintenance of this educational site. Donate at PayPal
© 2020 Marshall PierceAdult Standard Infusion Rate Charts Adult Standard Infusion Rate Calculator, Web-Based
Aminoglycoside and Vancomycin Excel downloadable Bayesian & Non-Bayesian dosing tool for Vancomycin and Aminoglycosides, open-compartment open model, for steady state or Non-Steady State dosing, using a non-linear fitting routine and the method of superposition. The tool creates a data file of data fittings that may be used to perform MUEs. The Solver Add-in must be available for the file to run. In Excel do the following: Click File, Click Options, Click Add-ins, Manage Excel Add-in Click Go, Check Solver Add-in and, select OK. Excel Program Instructions
Aminoglycosides Pharmacokinetic Dosing Information and Details
AUC
Calculations for One and Two-Compartment Models with a Downloadable Excel File.
Basic Pharmacokinetics & One-Compartment Model Equations
Bayesian Pharmacokinetics One-Compartment Model
Bayesian Pharmacokinetics Two-Compartment
Model
Biography of Website
Author
Creatinine Clearance
Overview
Creatinine Clearance
Calculator Web Based
Digoxin
Pharmacokinetic Dosing Information and Details
Digoxin Dosing
Calculator and Data Fitting For Troughs, Web-Based
Digoxin Dosing Calculator Using Population
Dosing or Levels Under Steady State or Non-Steady State Conditions,
Download
Solver Add-in must be available for
the file to run. In Excel do the following: Click File, Click Options, Click Add-ins, Manage Excel Add-in
Click Go, Check Solver Add-in, and select OK.
Digoxin Excel downloadable Bayesian Digoxin dosing tool, Open-compartment open model, for steady state or non-steady state dosing using the method of superposition.
This is a more versatile tool than the one above. The tool creates a data file of data fittings that may be used to perform MUEs. The Solver Add-in must be available for the file to run. In Excel do the following: Click File, Click Options, Click Add-ins, Manage Excel Add-in Click Go, Check Solver Add-in, and select OK.
Hepatic Disease Score Calculator, Web-Based
Lithium Pharmacokinetic Dosing Information and Details
Lithium Dosing Using
Non-Steady State or Steady State Levels, Single Level After Test Dose, Or Multiple Levels After Test
Dose Calculator
Download
Lithium
Dosing Calculator and Data Fitting for 12-hour post-dose Levels,
Web-Based
Phenobarbital Pharmacokinetic Information and Details
Phenobarbital Dosing Calculator Using Population Dosing or Levels Under
Steady State and Non-Steady State Conditions,
Download
Solver Add-in must be available for
the file to run. In Excel do the following: Click File, Click Options, Click Add-ins, Manage Excel Add-in
Click Go, Check Solver Add-in, and select OK.
Phenytoin Pharmacokinetic Dosing Information
and Details
Phenytoin Bayesian
Dosing Calculator, Using the Lambert W Function to Explicitly Solve the
Michaelis-Menten Equation, Downloadable Excel File.
The spreadsheet contains a VB macro and requires the solver
add-in to be available for the file to run. To install Solver in Excel do the following: Click File, Click
Options, Click Add-ins, Manage Excel Add-in Click Go, Check Solver Add-in, and
select OK. Then save the file.
Phenytoin Dosing Calculator, The spreadsheet contains several tabs which are
used for specific dosing scenarios described on each tab using the
methods discussed in Winter's Basic Clinical Pharmacokinetic. Provided as a downloadable Excel
file.
References
Simplified Pharmacokinetic Dosing Equations
Theophylline Dosing
Calculator and Data Fitting For Troughs, Web-Based
Vancomycin Pharmacokinetic Dosing Information and Details
Vancomycin
Bayesian AUC Dosing Calculator For Steady State Levels Using a Peak and Trough,
Downloadable Excel File.
Vancomycin Bayesian AUC Dosing Calculator, Downloadable Excel File, open compartment open model, for
use with varying dosing frequencies, doses, and steady state or Non-Steady State
levels using the method of superposition. The tool creates a data file of data fittings that may be used to perform MUEs. The Solver Add-in must be available for the file to run. In Excel do the following: Click File, Click Options, Click Add-ins, Manage Excel Add-in Click Go, Check Solver Add-in, and select OK.
Excel
Program Instructions
Vancomycin
Dosing Charts: Overview of Dosing Charts,
Vancomycin
Dosing Chart I &
Vancomycin
Dosing Chart II
Vancomycin Dosing for High Flux Dialysis
Vancomycin
AUC Dosing Calculator and Data Fitting For Troughs,
Web-Based
Vancomycin AUC
Dosing Calculator and Data Fitting For Peaks & Troughs, Web-Based
Vancomycin Bayesian Dosing
Calculator and Data Fitting For Steady-State or Non-Steady State
Levels Using A Simplex Non-Linear Data Fitting Algorithm With Database
Connectivity, Web-Based
Register-Login
Registration is required to use this application.
Registration and program use are free. Registered users may save,
retrieve, and update data in a database including the following: patient
demographic data, dosing, serum level, and serum creatinine history.
Patient data is stored using a user supplied HIPPA compliant identifier. Patient
names are not to be used. The patient's fourteen most recent saved doses,
levels, and serum creatinines may be retrieved and more data can be added when
fitting the patients current serum levels. Up to 30 doses, levels and serum creatinines
can be included in the data fitting. Data fittings may be Bayesian or
Non-Bayesian. Volume of distribution and clearance or just clearance can be
determined during data fitting. Changes in serum creatinine may be incorporated in the data
fitting if desired. Entered data is only available to the entering user so
other users may
not see the user's data. Users may download an Excel compatible CVS file of their patient
data fittings to compare predicted versus actual levels and to perform other
data analyses.
Future planed enhances include:
Data analysis to
optimization elimination rate and volume of distribution equations will be
performed when sufficient data is available.
Graphical displays of the
patient's data fitting.
Other drugs will be added to
this dosing tool.
Vancomycin Pharmacokinetic Dosing: Analysis of Patient Data &
Optimization of Kinetic Parameters
Monte Carlo Analysis of
One-Compartment Vancomycin Bayesian Pharmacokinetic Dosing Using a Peak & Trough, Trough, or Peak Serum Level For AUC Calculations
Vancomycin Two-Compartment Model
Intermittent Infusion Pharmacokinetics
This site is developed and maintained for educational use. No warranties
are expressed or implied.
If you have questions or suggestions concerning the dosing tools please contact Marshall Pierce PharmD.
Please help support the development and maintenance of this educational site. Donate at PayPal
© 2020 Marshall Pierce