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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00024924157398,null,1.228550184082331E-7,185.00026774159892,0,-6.6408028547752388E-3,185.00026774159892]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00026774159892,null,1.2285479112635286E-7,185.0002862416257,0,-6.6407899061359729E-3,185.0002862416257]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.0002862416257,null,1.2285456384487037E-7,185.00030474165433,0,-6.6407769575207928E-3,185.00030474165433]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00030474165433,null,1.2285433656378568E-7,185.00032324168481,0,-6.640764008929702E-3,185.00032324168481]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00032324168481,null,1.2285410928309873E-7,185.00034174171714,0,-6.640751060362696E-3,185.00034174171714]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"AB77","v":185.00034174171714},null,{"$f":"($W$59*EXP(-0.1*V78))","v":1.2285388200281E-7},{"$f":"V78+0.0000001*V78","v":185.00036024175131},{"$f":"(W78*EXP(-0.1*Y78))","v":0},{"$f":"(Z78-X78)/(Y78-V78)","v":-6.640738111819801E-3},{"$f":"V78-X78/AA78","v":185.00036024175131}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00036024175131,null,1.2285365472291862E-7,185.00037874178733,0,-6.6407251633009718E-3,185.00037874178733]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00037874178733,null,1.2285342744342501E-7,185.0003972418252,0,-6.6407122148062284E-3,185.0003972418252]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.0003972418252,null,1.2285320016432916E-7,185.00041574186491,0,-6.6406992663355724E-3,185.00041574186491]
[null,null,"F(x)","First Derivative of F(x)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00041574186491,null,1.2285297288563107E-7,185.00043424190648,0,-6.6406863178890023E-3,185.00043424190648]
["initial then estimated next x ",null,"3x^3+2.5*x^2-5x-11=0","9X^2+5x-5","F(x)/F'(x)","new x",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00043424190648,null,1.2285274560733122E-7,185.00045274194989,0,-6.6406733694665456E-3,185.00045274194989]
[-20,null,{"$f":"3*(A84^3)+2.5*(A84^2)-5*A84-11","v":-22911},{"$f":"9*(A84^2)+5*A84-5","v":3495},{"$f":"C84/D84","v":-6.5553648068669528},{"$f":"A84-E84","v":-13.444635193133047},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00045274194989,null,1.2285251832942868E-7,185.00047124199517,0,-6.6406604108660717E-3,185.00047124199517]
[{"$f":"F84","v":-13.444635193133047},null,{"$f":"3*(A85^3)+2.5*(A85^2)-5*A85-11","v":-6782.5660810703357},{"$f":"9*(A85^2)+5*A85-5","v":1554.6007633222202},{"$f":"C85/D85","v":-4.3628989777258464},{"$f":"A85-E85","v":-9.0817362154072008},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00047124199517,null,1.2285229105192348E-7,185.0004897420423,0,-6.6406474624917606E-3,185.0004897420423]
[{"$f":"F85","v":-9.0817362154072008},null,-2006.5249719529613,691.89271309911226,-2.9000521814507541,-6.1816840339564472,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.0004897420423,null,1.2285206377481649E-7,185.00050824209129,0,-6.6406345141415612E-3,185.00050824209129]
[-6.1816840339564472,null,-593.22464552834094,308.01053729126625,-1.9259881520461282,-4.2556958819103192,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00050824209129,null,1.2285183649810684E-7,185.00052674214211,0,-6.640621565815426E-3,185.00052674214211]
[-4.2556958819103192,null,-175.6682052970549,136.72004754422446,-1.2848752502096079,-2.9708206317007111,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,185.00052674214211,null,1.2285160922179492E-7,185.00054524219479,0,-6.6406086175133747E-3,185.00054524219479]
[-2.9708206317007111,null,-52.740844171281715,59.577873873143943,-0.88524213340643942,-2.0855784982942716]
[-2.0855784982942716,null,-16.912545742866893,23.718846561455141,-0.71304250394498592,-1.3725359943492856]
[-1.3725359943492856,null,-7.1846590053954538,5.092015530313013,-1.4109656505611252,3.842965621183958E-2]
[3.842965621183958E-2,null,-11.188285921682994,-4.7945601726517602,2.3335374922398797,-2.2951078360280404]
[-2.2951078360280404,null,-22.624240013059499,30.932140630835626,-0.73141527070731893,-1.5636925653207214]
[{"$f":"F93","v":-1.5636925653207214},null,{"$f":"3*(A94^3)+2.5*(A94^2)-5*A94-11","v":-8.5390167059661444},{"$f":"9*(A94^2)+5*A94-5","v":9.1877471229500784},{"$f":"C94/D94","v":-0.92939178578789239},{"$f":"A94-E94","v":-0.63430077953282904}]
[-0.63430077953282904,null,-7.5882613345809578,-4.5504665874205532,1.6675787391908723,-2.3018795187237013]
[-2.3018795187237013,null,-22.834536140562577,31.178446274858423,-0.73238210587086949,-1.5694974128528318]
[-1.5694974128528318,null,-8.5927407385951327,9.3224120963014325,-0.92172933891264164,-0.6477680739401902]
[-0.6477680739401902,null,-7.5275681458007124,-4.4624090711552977,1.6868843769743993,-2.3346524509145894]
[-2.3346524509145894,null,-23.876016999997095,32.382156344480549,-0.73732016935514233,-1.5973322815594471]
[-1.5973322815594471,null,-8.8613007388885876,9.976572351609942,-0.88821094325633987,-0.7091213383031072]
[-0.7091213383031072,null,-7.2670121584811067,-4.0199290395844276,1.8077463773421125,-2.5168677156452199]
[-2.5168677156452199,null,-30.409328775472854,39.427269304288586,-0.77127656345617546,-1.7455911521890446]
[-1.7455911521890446,null,-10.611235085206452,13.695840474460866,-0.77477794115619336,-0.97081321103285123]
[-0.97081321103285123,null,-6.5346493452619683,-1.3717614387210171,4.7636922578569125,-5.7345054688897639]
[-5.7345054688897639,null,-465.84603681602226,262.28844941009066,-1.7760829265022924,-3.9584225423874715]
[{"$f":"F105","v":-3.9584225423874715},null,{"$f":"3*(A106^3)+2.5*(A106^2)-5*A106-11","v":-138.10997786801042},{"$f":"9*(A106^2)+5*A106-5","v":116.2298685047943},{"$f":"C106/D106","v":-1.1882485943130323},{"$f":"A106-E106","v":-2.7701739480744392}]
[-2.7701739480744392,null,-41.738282933121319,50.213903582940738,-0.83120968407047213,-1.938964264003967]
[-1.938964264003967,null,-13.77531050018224,19.14142043374018,-0.71965978428125377,-1.2193044797227133]
[-1.2193044797227133,null,-6.6249514648289978,2.2838083298333212,-2.9008351437760567,1.6815306640533434]
[1.6815306640533434,null,1.9250228670271667,28.85556168763182,6.6712368584815218E-2,1.6148182954685282]
[1.6148182954685282,null,7.7589109270046919E-2,26.542834623761586,2.9231659078562716E-3,1.6118951295606718]
[1.6118951295606718,null,1.4547344489024283E-4,26.443328826116094,5.5013287414317371E-6,1.6118896282319304]
[1.6118896282319304,null,5.1471005235725897E-10,26.443141703574689,1.9464784409020446E-11,1.6118896282124655]
[1.6118896282124655,null,0,26.443141702912605,0,1.6118896282124655]
[1.6118896282124655,null,0,26.443141702912605,0,1.6118896282124655]
[1.6118896282124655,null,0,26.443141702912605,0,1.6118896282124655]
[1.6118896282124655,null,0,26.443141702912605,0,1.6118896282124655]
[1.6118896282124655,null,0,26.443141702912605,0,1.6118896282124655]
[1.6118896282124655,null,0,26.443141702912605,0,1.6118896282124655]

{"sheet":"Trough Data Fitting","index":1,"n_rows":57,"n_cols":141,"rows_kept":57,"cut":false,"hidden":false,"merged":[[1,1,1,2],[23,1,23,2],[12,1,12,2]]}
[null,null,null,null,null,null,"Phenytoin Michaelis Menten (Capacity-Limited) Pharmacokinetics One Compartment Model "]
[null,"Demographic Data Input",null,null,null,null,"Bayesian Data Fitting of Troughs to Calculate Km and Vmax. Vd is not fit as peak levels are not entered or analyzed.",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Sex"]
[null,"Select Age Group (Years) Drop Down Box","> 59",null,null,null,"Dosing with or without a Loading Dose Followed by a  Uniform Dose and Frequency",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Male"]
[null,"Input Height (inches)",null,null,null,null,"Marshall Pierce PharmD",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Female"]
[null,"Input Weight (kg)",null,null,null,null,"https://pkineticdrugdosing.com/documents/phenytoin.html"]
[null,"Select Sex (Drop Down Box)","Male",null,null,"Instructions:"]
[null,"Input Serum Albumin (grams/dL) Normal is 4.4 g/dL",4.4000000000000004,null,null,"Enter information in the blue fields. Click new patient button to clear prior data."]
[null,"Select if Hemodialysis Patient (Drop Down Box)","No",null,null,"Enter the concentration before the first dose and the hours the level drawn before the first dose . "]
[null,"Select Dosage Form Drop Down Box","Capsule",null,null,"This assumes the patient was on prior therapy. If there was no prior therapy leave the cells blank."]
[null,"Fraction of Dosage Form That Is Pure Drug",{"$f":"IF(C9=\"Capsule\",0.92,IF(C9=\"Injection\",0.92,IF(C9=\"Tablet\",1,IF(C9=\"Suspension\",1))))","v":0.92},null,null,"Enter know troughs. The troughs below a dose are the trough just before the dose. Troughs should be drawn just before a dose."]
[null,"Ideal Body Weight (kg) calculated",{"$f":"IF(C6=\"Male\", (C4-60)*2.3+50,(C4-60)*2.3+45.5)","v":-88},null,null,"If extended release phenytoin capsules are being administered divide the total daily dose into 3 to 4 maintenance doses and set the Tau accordingly."]
[null,"Ideal Body Weight Used (kg)",{"$f":"IF(C5<C11,C5,C11)","v":-88}]
[null,"Population Mean Parameters",null,"Fit Parameters",null,"Data Fitting:"]
[null,"Calculated Vd (Liters)",{"$f":"IF(C5>C11,0.65*C12+1.33*(C5-C12),C5*0.65)","v":59.84},{"$f":"C14","v":59.84},null,"Click the fit data button."]
[null,"Km (mg/liter) population mean",{"$f":"VLOOKUP(C3,lookuparray!A2:F8,5,FALSE)","v":5.8},{"$f":"C15","v":5.8},null,"All doses are modeled as  bolus doses. If SR or extended release products are used divide the total daily dose into 3 to 4 doses and set the Tau accordingly. "]
[null,"Vmax (mg/kg/day) population mean",{"$f":"VLOOKUP(C3,lookuparray!A2:F8,4,FALSE)","v":7},{"$f":"D17/C12","v":7},null,"Fitting of levels after a loading dose.: Enter the loading dose, set Tau to a frequeny that repeats at time(s) of the post dose level(s), and set maintenance dose to 0. "]
[null,"Vmax Calculated (mg/day)",{"$f":"C16*C12","v":-616},{"$f":"D18*24","v":-616},null,"If prior therapy has been given you must have a pre Loading Dose level.  You can then fit the parameters after a loading dose.  Draw levels 6 and 12 hours post dose for data fitting.  "]
[null,"Vmax Calculated (mg/hours)",{"$f":"C16*C12/24","v":-25.666666666666668},{"$f":"D19*D14","v":-25.666666666666668},null,"After fitting levels enter a maintenance dose and adjust Tau as needed.  Order follow up levels ever 2 to 3 days."]
[null,"Vmax Calculated (mg/hour/liter)",{"$f":"C16*C12/(24*C14)","v":-0.42892156862745096},{"$f":"C19","v":-0.42892156862745096}]
[null,"Input Loaing Dose(mg) or enter the Maintenance Dose if no LD is given.",null,null,null,"Please review the information at the link above for a better understanding of phenytoin kinetics. "]
[null,"Cp Calculated Post Loading Dose(mg/L)",{"$f":"C20*C10/C14","v":0}]
[null,"Input Tau (Hours) ",null,null,null,"The graphic below demonstrates predicted levels using population parameters before levels are fit and patient specific after levels are fit."]
[null,"Input Maintenance Dose (mg)",null,{"$f":"IF(OR(D25<=0,D31>20),\"The dose it too high and is above or equal to Vmax. Reduce the dose or increase the interval.\",\"\")","v":{"$error":"#DIV/0!"}}]
[null,"Population Based Dosing",null,"Individualized Dosing"]
["hide","Predicted Cssavg Calculated (mg/L)",{"$f":"(C15*$C23*$C10/$C22)/(C18-$C23*$C10/$C22)","v":{"$error":"#DIV/0!"}},{"$f":"(D15*$C23*$C10/$C22)/(D18-$C23*$C10/$C22)","v":{"$error":"#DIV/0!"}}]
[null,"Accumulation",{"$f":"$C$23*$C$10/(C$14*(1-EXP(($C$23*$C$10-C$19*C$14*$C$22)/(C$15*C$14))))","v":{"$error":"#DIV/0!"}},{"$f":"$C$23*$C$10/(D$14*(1-EXP(($C$23*$C$10-D$19*D$14*$C$22)/(D$15*D$14))))","v":{"$error":"#DIV/0!"}}]
[null,"X of lamber equation calculated",{"$f":"(C26/C$15)*EXP((C26-C$19*$C$22)/C$15)","v":{"$error":"#DIV/0!"}},{"$f":"(D26/D$15)*EXP((D26-D$19*$C$22)/D$15)","v":{"$error":"#DIV/0!"}}]
[null,"Wo of x calculated",{"$f":"1.4586887*LN(1.2*C27/(LN(2.4*C27/(LN(1+2.4*C27)))))-0.4586887*LN(2*C27/(LN(1+2*C27)))","v":{"$error":"#DIV/0!"}},{"$f":"1.4586887*LN(1.2*D27/(LN(2.4*D27/(LN(1+2.4*D27)))))-0.4586887*LN(2*D27/(LN(1+2*D27)))","v":{"$error":"#DIV/0!"}}]
[null,"Predicted Css trough calculated (mg/L)",{"$f":"C$15*C28","v":{"$error":"#DIV/0!"}},{"$f":"D$15*D28","v":{"$error":"#DIV/0!"}}]
[null,"Predicted Css max calculated (mg/L)",{"$f":"C29+$C$23*$C$10/C$14","v":{"$error":"#DIV/0!"}},{"$f":"D29+$C$23*$C$10/D$14","v":{"$error":"#DIV/0!"}}]
[null,"Predicted Caverage calculated (mg/L)",{"$f":"(C29+C30)/2","v":{"$error":"#DIV/0!"}},{"$f":"(D29+D30)/2","v":{"$error":"#DIV/0!"}}]
[null,"Cp Average Steady State Equivalent to Normal Protein Binding. This row applies if low albumin or dialysis. (mg/L)",{"$f":"IF(C31=\"\",\"\",IF($C8=\"No\",C31/(0.9*($C$7/4.4)+0.1),C31/(0.9*0.48*($C$7/4.4)+0.1)))","v":{"$error":"#DIV/0!"}},{"$f":"IF(D31=\"\",\"\",IF($C8=\"No\",D31/(0.9*($C$7/4.4)+0.1),D31/(0.9*0.48*($C$7/4.4)+0.1)))","v":{"$error":"#DIV/0!"}}]
[null,"Cp Average Steady State Equivalent to Normal Protein Binding. This row applies if free levels are entered below. (mg/L)",{"$f":"IF(ISNUMBER($C36),$C36/0.1*C31,\"\")","v":""},{"$f":"IF(ISNUMBER($C36),$C36/0.1*D31,\"\")","v":""}]
[null,"Input Most Recent Free level if drawn (mg/L)"]
[null,"Input Total Level Assoociated with Free Level (mg/L)"]
[null,"Free Fraction Calculated  (Normal free faction is 0.1)",{"$f":"IF(AND(C34<>\"\",C35<>\"\"),C34/C35,\"\")","v":""}]
[null,"Time to 90% of Steady State (Days) from Start of Therapy. Assumes No Loading Dose and No Drug is on Board at Start of Therapy.",{"$f":"(C15*C14/(C18-$C23*$C10/$C22)^2)*(2.3*C18-0.9*$C23*$C10/$C22)/24","v":{"$error":"#DIV/0!"}},{"$f":"(D15*D14/(D18-$C23*$C10/$C22)^2)*(2.3*D18-0.9*$C23*$C10/$C22)/24","v":{"$error":"#DIV/0!"}}]
[]
[]
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[null,"Time absolute (Hours)",null,0,{"$f":"$C22+D41","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"$C22+AJ41","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"$C22+BP41","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"$C22+CV41","v":0},0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,{"$f":"$C22+EB41","v":0},0,0,0,0,0,0,0,0]
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[null,"Peak Expected (mg/L) Just After Dose Time",null,{"$f":"$C20*$C10/$D14+D47","v":0},{"$f":"E47+$C23*$C10/$D14","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"AK47+$C23*$C10/$D14","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"BQ47+$C23*$C10/$D14","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"CW47+$C23*$C10/$D14","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"EC47+$C23*$C10/$D14","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"EK47+$C23/$D14","v":{"$error":"#DIV/0!"}}]
[null,"Trough Expected  (mg/L) Just Before Dose Time",null,{"$f":"IF($C50>0,$D15*C44,0)","v":0},{"$f":"$D15*D44","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"$D15*AJ44","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"$D15*BP44","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"$D15*CV44","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$f":"$D15*EB44","v":{"$error":"#DIV/0!"}},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"}]
[]
["Hide","Input Measured Peak (mg/L)"]
[null,"Input Measured Trough (mg/L)"]
[null,"Input Time (Hours) Level Drawn Before 1st Dose"]
[]
["Hide","Square of Peak Errors",null,{"$f":"IF(ISNUMBER(D49),((D49-D46)^2)/(0.1*(D46))^2,\"\")","v":""},{"$f":"IF(ISNUMBER(E49),((E49-E46)^2)/(0.1*(E46))^2,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(BQ49),((BQ49-BQ46)^2)/(0.1*(BQ46))^2,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(EC49),((EC49-EC46)^2)/(0.1*(EC46))^2,\"\")","v":""},"","","","","","",""]
[null,"Square of Trough Errors",null,{"$f":"IF(ISNUMBER(D50),((D50-E47)^2)/(0.1*(D50))^2,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(AJ50),((AJ50-AK47)^2)/(0.1*(AJ50))^2,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(BP50),((BP50-BQ47)^2)/(0.1*(BP50))^2,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(CV50),((CV50-CW47)^2)/(0.1*(CV50))^2,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(EB50),((EB50-EC47)^2)/(0.1*(EB50))^2,\"\")","v":""},"","","","","","","",""]
[]
[null,"Bayesian Fitting ",1]
[null,"Sum of Square of Errors",{"$f":"IF(C56=1,SUM(D53:EJ54)+(D15-C15)^2/(0.4*C15)^2+ (C19-D19)^2/(C19*0.4)^2,SUM(D53:EJ54)+(C14-D14)^2/(0.4*D14)^2+(D15-C15)^2/(0.4*C15)^2+ (C19-D19)^2/(C19*0.3)^2)","v":0}]

{"sheet":"Peak Trough Data Fitting","index":2,"n_rows":60,"n_cols":199,"rows_kept":60,"cut":false,"hidden":false,"merged":[[1,1,1,2],[12,1,12,2],[23,1,23,2]]}
[null,null,null,null,null,null,"Phenytoin Michaelis Menten (Capacity-Limited) Pharmacokinetics One Compartment Open Model "]
[null,"Demographic Data Input",null,null,null,null,"Bayesian Data Fitting of Steady State or Non Steady State Dosing and Serum Levels",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Sex"]
[null,"Select Age Group (Years) Drop Down Box","> 59",null,null,null,"Marshall Pierce PharmD",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Male"]
[null,"Input Height (inches)",70,null,null,null,"https://pkineticdrugdosing.com/documents/phenytoin.html",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Female"]
[null,"Input Weight (kg)",70]
[null,"Select Sex (Drop Down Box)","Male",null,null,"Instructions:"]
[null,"Input Serum Albumin (grams/dL) Normal is 4.4 g/dL",4.4000000000000004,null,null,"Click new patient button to clear prior data. Enter information in the blue fields. "]
[null,"Select if Hemodialysis Patient (Drop Down Box)","No",null,null,"If levels are to be analyzed enter the concentration before the first dose and time of level. "]
[null,"Select Dosage Form Drop Down Box","Capsule",null,null,"This assumes the patient was on prior therapy. If there was no prior therapy leave both cells blank."]
[null,"Fraction of Dosage Form That Is Pure Drug",{"$f":"IF(C9=\"Capsule\",0.92,IF(C9=\"Injection\",0.92,IF(C9=\"Tablet\",1,IF(C9=\"Suspension\",1))))","v":0.92},null,null,"Enter the dosing history including the dose and time for all doses that contribute to the serum levels to be analyzed. "]
[null,"Ideal Body Weight (kg) calculated",{"$f":"IF(C6=\"Male\", (C4-60)*2.3+50,(C4-60)*2.3+45.5)","v":73},null,null,"Dose and levels are enter chronologically from left to right. Levels should be enter after the dose that are associated with and before the next dose."]
[null,"Ideal Body Weight Used (kg)",{"$f":"IF(C5<C11,C5,C11)","v":70},null,null,"Enter know levels and time of levels. Peaks should be drawn 2 hours after end of a fos/phenytoin infusion."]
[null,"Population Mean Parameters",null,"Fit Parameters",null,"All does are modeled as bolus doses. If extended release phenytoin capsules are being administered divide "]
[null,"Calculated Vd (Liters)",{"$f":"IF(C5>C11,0.65*C12+1.33*(C5-C12),C5*0.65)","v":45.5},45.5,null,"the total daily dose into 3 to 4 maintenance doses and set the Tau accordingly."]
[null,"Km (mg/liter) population mean",{"$f":"VLOOKUP(C3,lookuparray!A2:F8,5,FALSE)","v":5.8},4.5302507722168048,null,"Data Fitting:"]
[null,"Vmax (mg/kg/day) population mean",{"$f":"VLOOKUP(C3,lookuparray!A2:F8,4,FALSE)","v":7},{"$f":"D17/C12","v":8.7924930854808672},null,"Select the type of fitting (1 without Vd, 2 with Vd). It is NOT recommended to fit Vd if a peak level was not drawn. Click the fit data button."]
[null,"Vmax Calculated (mg/day)",{"$f":"C16*C12","v":490},{"$f":"D18*24","v":615.47451598366069},null,"After fitting levels adjust the maintenance dose and Tau as needed to maintain therapeutic levels for individualized dosing.  "]
[null,"Vmax Calculated (mg/hours)",{"$f":"C16*C12/24","v":20.416666666666668},{"$f":"D19*D14","v":25.644771499319194},null,"Order follow up levels every 3-5 days."]
[null,"Vmax Calculated (mg/hour/liter)",{"$f":"C16*C12/(24*C14)","v":0.44871794871794873},0.56362135163338889,null,"Please review the information at the link above for a better understanding of phenytoin kinetics before using the calculator. "]
[null,"Input Loaing Dose(mg) ",1000,null,null,"No warranties are expressed or implied and the dosing tool is made available for for educational use."]
[null,"Calculated Post Loading Dose Level(mg/L)",{"$f":"C20*C10/C14","v":20.219780219780219}]
[null,"Input Dosage Interval, Tau (Hours) ",6,null,null,"The graphic below demonstrates predicted levels using population parameters before levels are fit and patient specific parameters after levels are fit for all doses entered."]
[null,"Input Maintenance Dose (mg)",100,{"$f":"IF(OR(D25<=0,D31>20),\"The dose it too high and is above or equal to Vmax. Reduce the dose or increase the interval.\",\"\")","v":""}]
[null,"Population Based Dosing",null,"Individualized Dosing"]
["hide","Predicted Cssavg Calculated (mg/L)",{"$f":"(C15*$C23*$C10/$C22)/(C18-$C23*$C10/$C22)","v":17.495081967213114},{"$f":"(D15*$C23*$C10/$C22)/(D18-$C23*$C10/$C22)","v":6.7365816538695862}]
[null,"Accumulation Factor",{"$f":"$C$23*$C$10/(C$14*(1-EXP(($C$23*$C$10-C$19*C$14*$C$22)/(C$15*C$14))))","v":18.525540665209036},{"$f":"$C$23*$C$10/(D$14*(1-EXP(($C$23*$C$10-D$19*D$14*$C$22)/(D$15*D$14))))","v":7.7980694413446541}]
[null,"X of lambert equation calculated",{"$f":"(C26/C$15)*EXP((C26-C$19*$C$22)/C$15)","v":48.967665515910134},{"$f":"(D26/D$15)*EXP((D26-D$19*$C$22)/D$15)","v":4.5628832688609844}]
[null,"Wo of x calculated",{"$f":"1.4586887*LN(1.2*C27/(LN(2.4*C27/(LN(1+2.4*C27)))))-0.4586887*LN(2*C27/(LN(1+2*C27)))","v":2.8404653786716247},{"$f":"1.4586887*LN(1.2*D27/(LN(2.4*D27/(LN(1+2.4*D27)))))-0.4586887*LN(2*D27/(LN(1+2*D27)))","v":1.274381635462527}]
[null,"Predicted Css trough calculated (mg/L)",{"$f":"C$15*C28","v":16.474699196295422},{"$f":"D$15*D28","v":5.7732683881530278}]
[null,"Predicted Css max calculated (mg/L)",{"$f":"C29+$C$23*$C$10/C$14","v":18.496677218273444},{"$f":"D29+$C$23*$C$10/D$14","v":7.7952464101310497}]
[null,"Predicted Caverage calculated (mg/L)",{"$f":"(C29+C30)/2","v":17.485688207284433},{"$f":"(D29+D30)/2","v":6.7842573991420387}]
[null,"Cp Average Steady State Equivalent to Normal Protein Binding. This row applies if low albumin or dialysis. (mg/L)",{"$f":"IF(C31=\"\",\"\",IF($C8=\"No\",C31/(0.9*($C$7/4.4)+0.1),C31/(0.9*0.48*($C$7/4.4)+0.1)))","v":17.485688207284433},{"$f":"IF(D31=\"\",\"\",IF($C8=\"No\",D31/(0.9*($C$7/4.4)+0.1),D31/(0.9*0.48*($C$7/4.4)+0.1)))","v":6.7842573991420387}]
[null,"Cp Average Steady State Equivalent to Normal Protein Binding. This row applies if free levels are entered below. (mg/L)",{"$f":"IF(ISNUMBER($C36),$C36/0.1*C31,\"\")","v":17.485688207284433},{"$f":"IF(ISNUMBER($C36),$C36/0.1*D31,\"\")","v":6.7842573991420387}]
[null,"Input Most Recent Free level if drawn (mg/L)",1]
[null,"Input Total Level Assoociated with Free Level (mg/L)",10]
[null,"Free Fraction Calculated  (Normal free faction is 0.1)",{"$f":"IF(AND(C34<>\"\",C35<>\"\"),C34/C35,\"\")","v":0.1}]
[null,"Time to 90% of Steady State (Days) from Start of Therapy. Assumes No Loading Dose and No Drug is on Board at Start of Therapy.",{"$f":"(C15*C14/(C18-$C23*$C10/$C22)^2)*(2.3*C18-0.9*$C23*$C10/$C22)/24","v":14.109891158290781},{"$f":"(D15*D14/(D18-$C23*$C10/$C22)^2)*(2.3*D18-0.9*$C23*$C10/$C22)/24","v":3.6497131475291589}]
[]
[]
[null,null,"Input Dose (mg)",100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100,null,null,100]
[null,"Input Date/Time of Dose month/day/year (xx/xx/xx)",null,"2023-08-01T06:00:00",null,null,"2023-08-01T12:00:00",null,null,"2023-08-01T18:00:00",null,null,"2023-08-02",null,null,"2023-08-02T06:00:00",null,null,"2023-08-02T12:00:00",null,null,"2023-08-02T18:00:00",null,null,"2023-08-03",null,null,"2023-08-03T06:00:00",null,null,"2023-08-03T12:00:00",null,null,"2023-08-03T18:00:00",null,null,"2023-08-04",null,null,"2023-08-04T06:00:00",null,null,"2023-08-04T12:00:00",null,null,"2023-08-04T18:00:00",null,null,"2023-08-05",null,null,"2023-08-05T06:00:00",null,null,"2023-08-05T12:00:00",null,null,"2023-08-05T18:00:00",null,null,"2023-08-06",null,null,"2023-08-06T06:00:00",null,null,"2023-08-06T12:00:00",null,null,"2023-08-06T18:00:00",null,null,"2023-08-07",null,null,"2023-08-07T06:00:00",null,null,"2023-08-07T12:00:00",null,null,"2023-08-07T18:00:00",null,null,"2023-08-08",null,null,"2023-08-08T06:00:00",null,null,"2023-08-08T12:00:00"]
[null,"Time absolute (Hours)",null,0,null,null,{"$f":"IF(AND(ISNUMBER(D41),ISNUMBER(G41)),(G41-$D41)*24,\"\")","v":6},null,null,{"$f":"IF(AND(ISNUMBER(G41),ISNUMBER(J41)),(J41-$D41)*24,\"\")","v":12},null,null,{"$f":"IF(AND(ISNUMBER(J41),ISNUMBER(M41)),(M41-$D41)*24,\"\")","v":18},null,null,{"$f":"IF(AND(ISNUMBER(M41),ISNUMBER(P41)),(P41-$D41)*24,\"\")","v":24},null,null,{"$f":"IF(AND(ISNUMBER(P41),ISNUMBER(S41)),(S41-$D41)*24,\"\")","v":30},null,null,{"$f":"IF(AND(ISNUMBER(S41),ISNUMBER(V41)),(V41-$D41)*24,\"\")","v":36},null,null,{"$f":"IF(AND(ISNUMBER(V41),ISNUMBER(Y41)),(Y41-$D41)*24,\"\")","v":42},null,null,{"$f":"IF(AND(ISNUMBER(Y41),ISNUMBER(AB41)),(AB41-$D41)*24,\"\")","v":48},null,null,{"$f":"IF(AND(ISNUMBER(AB41),ISNUMBER(AE41)),(AE41-$D41)*24,\"\")","v":54},null,null,{"$f":"IF(AND(ISNUMBER(AE41),ISNUMBER(AH41)),(AH41-$D41)*24,\"\")","v":60},null,null,{"$f":"IF(AND(ISNUMBER(AH41),ISNUMBER(AK41)),(AK41-$D41)*24,\"\")","v":66},null,null,{"$f":"IF(AND(ISNUMBER(AK41),ISNUMBER(AN41)),(AN41-$D41)*24,\"\")","v":72},null,null,{"$f":"IF(AND(ISNUMBER(AN41),ISNUMBER(AQ41)),(AQ41-$D41)*24,\"\")","v":78},null,null,{"$f":"IF(AND(ISNUMBER(AQ41),ISNUMBER(AT41)),(AT41-$D41)*24,\"\")","v":84},null,null,{"$f":"IF(AND(ISNUMBER(AT41),ISNUMBER(AW41)),(AW41-$D41)*24,\"\")","v":90},null,null,{"$f":"IF(AND(ISNUMBER(AW41),ISNUMBER(AZ41)),(AZ41-$D41)*24,\"\")","v":96},null,null,{"$f":"IF(AND(ISNUMBER(AZ41),ISNUMBER(BC41)),(BC41-$D41)*24,\"\")","v":102},null,null,{"$f":"IF(AND(ISNUMBER(BC41),ISNUMBER(BF41)),(BF41-$D41)*24,\"\")","v":108},null,null,{"$f":"IF(AND(ISNUMBER(BF41),ISNUMBER(BI41)),(BI41-$D41)*24,\"\")","v":114},null,null,{"$f":"IF(AND(ISNUMBER(BI41),ISNUMBER(BL41)),(BL41-$D41)*24,\"\")","v":120},null,null,{"$f":"IF(AND(ISNUMBER(BL41),ISNUMBER(BO41)),(BO41-$D41)*24,\"\")","v":126},null,null,{"$f":"IF(AND(ISNUMBER(BO41),ISNUMBER(BR41)),(BR41-$D41)*24,\"\")","v":132},null,null,{"$f":"IF(AND(ISNUMBER(BR41),ISNUMBER(BU41)),(BU41-$D41)*24,\"\")","v":138},null,null,{"$f":"IF(AND(ISNUMBER(BU41),ISNUMBER(BX41)),(BX41-$D41)*24,\"\")","v":144},null,null,{"$f":"IF(AND(ISNUMBER(BX41),ISNUMBER(CA41)),(CA41-$D41)*24,\"\")","v":150},null,null,{"$f":"IF(AND(ISNUMBER(CA41),ISNUMBER(CD41)),(CD41-$D41)*24,\"\")","v":156},null,null,{"$f":"IF(AND(ISNUMBER(CD41),ISNUMBER(CG41)),(CG41-$D41)*24,\"\")","v":162},null,null,{"$f":"IF(AND(ISNUMBER(CG41),ISNUMBER(CJ41)),(CJ41-$D41)*24,\"\")","v":168},null,null,{"$f":"IF(AND(ISNUMBER(CJ41),ISNUMBER(CM41)),(CM41-$D41)*24,\"\")","v":174},{"$f":"IF(AND(ISNUMBER(CK41),ISNUMBER(CN41)),(CN41-$D41)*24,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(AND(ISNUMBER(EW41),ISNUMBER(EZ41)),(EZ41-$D41)*24,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"$C22+GP42","v":{"$error":"#VALUE!"}}]
[null,null,"Pre Dose 1","Dose 1",null,null,"Dose 2",null,null,"Dose 3",null,null,"Dose 4",null,null,"Dose 5",null,null,"Dose 6",null,null,"Dose 7",null,null,"Dose 8",null,null,"Dose 9",null,null,"Dose 10",null,null,"Dose 11",null,null,"Dose 12",null,null,"Dose 13",null,null,"Dose 14",null,null,"Dose 15",null,null,"Dose 16",null,null,"Dose 17",null,null,"Dose 18",null,null,"Dose 19",null,null,"Dose 20",null,null,"Dose 21",null,null,"Dose 22",null,null,"Dose 23",null,null,"Dose 24",null,null,"Dose 25",null,null,"Dose 26",null,null,"Dose 27",null,null,"Dose 28",null,null,"Dose 29",null,null,"Dose 30","Dose 31","Dose 32","Dose 33","Dose 34","Dose 35","Dose 36","Dose 37","Dose 38","Dose 39","Dose 40","Dose 41","Dose 42","Dose 43","Dose 44","Dose 45","Dose 46","Dose 47","Dose 48","Dose 49","Dose 50","Dose 51","Dose 52","Dose 53","Dose 54","Dose 55","Dose 56","Dose 57","Dose 58","Dose 59","Dose 60","Dose 61","Dose 62","Dose 63","Dose 64","Dose 65","Dose 66","Dose 67","Dose 68","Dose 69","Dose 70","Dose 71","Dose 72","Dose 73","Dose 74","Dose 75","Dose 76","Dose 77","Dose 78","Dose 79","Dose 80","Dose 81","Dose 82","Dose 83","Dose 84","Dose 85","Dose 86","Dose 87","Dose 88","Dose 89","Dose 90","Dose 91","Dose 92","Dose 93","Dose 94","Dose 95","Dose 96","Dose 97","Dose 98","Dose 99","Dose 100","Dose 101","Dose 102","Dose 103","Dose 104","Dose 105","Dose 106","Dose 107","Dose 108","Dose 109","Dose 110","Dose 111","Dose 112","Dose 113","Dose 114","Dose 115","Dose 116","Dose 117","Dose 118","Dose 119","Dose 120","Dose 121","Dose 122","Dose 123","Dose 124","Dose 125","Dose 126","Dose 127","Dose 128","Dose 129","Dose 130","Dose 131","Dose 132","Dose 133","Dose 134","Dose 135","Dose 136","Dose 137"]
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["Hide",null,null,{"$f":"D49","v":0},null,null,{"$f":"G49","v":1.1609244831801908},null,null,{"$f":"J49","v":1.9736527325576469},null,null,{"$f":"M49","v":2.5879679625396235},null,null,{"$f":"P49","v":3.0720687820953092},null,null,{"$f":"S49","v":3.4637166456948063},null,null,{"$f":"V49","v":3.7863441596114837},null,null,{"$f":"Y49","v":4.0556276095056205},null,null,{"$f":"AB49","v":4.2826290748962714},null,null,{"$f":"AE49","v":4.4754710906359652},null,null,{"$f":"AH49","v":4.6403033851878268},null,null,{"$f":"AK49","v":4.7818962920077199},null,null,{"$f":"AN49","v":4.9040232268991959},null,null,{"$f":"AQ49","v":5.0097172269218495},null,null,{"$f":"AT49","v":5.1014488199092796},null,null,{"$f":"AW49","v":5.1812528587337701},null,null,{"$f":"AZ49","v":5.2508211666163414},null,null,{"$f":"BC49","v":5.3115716362644081},null,null,{"$f":"BF49","v":5.3647007166543634},null,null,{"$f":"BI49","v":5.4112239278146639},null,null,{"$f":"BL49","v":5.4520075834405368},null,null,{"$f":"BO49","v":5.4877939466338219},null,null,{"$f":"BR49","v":5.5192214056652888},null,null,{"$f":"BU49","v":5.5468408207942801},null,null,{"$f":"BX49","v":5.5711288900135889},null,null,{"$f":"CA49","v":5.5924991671349016},null,null,{"$f":"CD49","v":5.6113112115846926},null,null,{"$f":"CG49","v":5.6278782370581943},null,null,{"$f":"CJ49","v":5.6424735433584603},null,null,{"$f":"CM49","v":5.6553359538872163},{"$f":"CN49","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"EZ49","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",""]
[null,null,"Time of Level & Level Before 1st Dose"]
[null,"Input Date/Time of Level            month/day/year (xx/xx/xx)",null,"Input Date/Time of Level            month/day/year (xx/xx/xx)",{"$f":"G41","v":"2023-08-01T12:00:00"},{"$f":"G41","v":"2023-08-01T12:00:00"},null,{"$f":"J41","v":"2023-08-01T18:00:00"},{"$f":"J41","v":"2023-08-01T18:00:00"},null,{"$f":"M41","v":"2023-08-02"},{"$f":"M41","v":"2023-08-02"},null,{"$f":"P41","v":"2023-08-02T06:00:00"},{"$f":"P41","v":"2023-08-02T06:00:00"},null,{"$f":"S41","v":"2023-08-02T12:00:00"},{"$f":"S41","v":"2023-08-02T12:00:00"},null,{"$f":"V41","v":"2023-08-02T18:00:00"},{"$f":"V41","v":"2023-08-02T18:00:00"},null,{"$f":"Y41","v":"2023-08-03"},{"$f":"Y41","v":"2023-08-03"},null,{"$f":"AB41","v":"2023-08-03T06:00:00"},{"$f":"AB41","v":"2023-08-03T06:00:00"},null,{"$f":"AE41","v":"2023-08-03T12:00:00"},{"$f":"AE41","v":"2023-08-03T12:00:00"},null,{"$f":"AH41","v":"2023-08-03T18:00:00"},{"$f":"AH41","v":"2023-08-03T18:00:00"},null,{"$f":"AK41","v":"2023-08-04"},{"$f":"AK41","v":"2023-08-04"},null,{"$f":"AN41","v":"2023-08-04T06:00:00"},{"$f":"AN41","v":"2023-08-04T06:00:00"},null,{"$f":"AQ41","v":"2023-08-04T12:00:00"},{"$f":"AQ41","v":"2023-08-04T12:00:00"},null,{"$f":"AT41","v":"2023-08-04T18:00:00"},{"$f":"AT41","v":"2023-08-04T18:00:00"},null,{"$f":"AW41","v":"2023-08-05"},{"$f":"AW41","v":"2023-08-05"},null,{"$f":"AZ41","v":"2023-08-05T06:00:00"},{"$f":"AZ41","v":"2023-08-05T06:00:00"},null,{"$f":"BC41","v":"2023-08-05T12:00:00"},{"$f":"BC41","v":"2023-08-05T12:00:00"},null,{"$f":"BF41","v":"2023-08-05T18:00:00"},{"$f":"BF41","v":"2023-08-05T18:00:00"},null,{"$f":"BI41","v":"2023-08-06"},{"$f":"BI41","v":"2023-08-06"},null,{"$f":"BL41","v":"2023-08-06T06:00:00"},{"$f":"BL41","v":"2023-08-06T06:00:00"},null,{"$f":"BO41","v":"2023-08-06T12:00:00"},{"$f":"BO41","v":"2023-08-06T12:00:00"},null,{"$f":"BR41","v":"2023-08-06T18:00:00"},{"$f":"BR41","v":"2023-08-06T18:00:00"},null,{"$f":"BU41","v":"2023-08-07"},{"$f":"BU41","v":"2023-08-07"},null,{"$f":"BX41","v":"2023-08-07T06:00:00"},{"$f":"BX41","v":"2023-08-07T06:00:00"},null,{"$f":"CA41","v":"2023-08-07T12:00:00"},{"$f":"CA41","v":"2023-08-07T12:00:00"},null,{"$f":"CD41","v":"2023-08-07T18:00:00"},{"$f":"CD41","v":"2023-08-07T18:00:00"},null,{"$f":"CG41","v":"2023-08-08"},{"$f":"CG41","v":"2023-08-08"},null,{"$f":"CJ41","v":"2023-08-08T06:00:00"},{"$f":"CJ41","v":"2023-08-08T06:00:00"},null,{"$f":"CM41","v":"2023-08-08T12:00:00"},{"$f":"CM41","v":"2023-08-08T12:00:00"}]
[null,"Input Measured Level (mg/L) ",null,"Input Measured Level (mg/L) ",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,4]
[]
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[null,"Square of Errors for Serum Levels",null,null,{"$f":"IF(ISNUMBER(E53),((E53-E49)^2)/(0.1*(E53))^2,\"\")","v":""},{"$f":"IF(ISNUMBER(F53),((F53-F49)^2)/(0.1*(F53))^2,\"\")","v":""},{"$f":"IF(ISNUMBER(G53),((G53-G49)^2)/(0.1*(G53))^2,\"\")","v":""},{"$f":"IF(ISNUMBER(H53),((H53-H49)^2)/(0.1*(H53))^2,\"\")","v":""},"","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(Y53),((Y53-Y49)^2)/(0.1*(Y53))^2,\"\")","v":1.9340193370686255E-2},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(BR53),((BR53-BR49)^2)/(0.1*(BR53))^2,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(ED53),((ED53-ED49)^2)/(0.1*(ED53))^2,\"\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",{"$f":"IF(ISNUMBER(GP53),((GP53-GP49)^2)/(0.1*(GP53))^2,\"\")","v":""}]
[]
[null,"Bayesian Fitting of                                       1= Km & Vmax, 2 =Km, Vmax, & Vd",1]
[null,"Sum of Square of Errors",{"$f":"IF(C59=1,SUM(E56:GP57)+(D15-C15)^2/(0.4*C15)^2+ (C19-D19)^2/(C19*0.4)^2,SUM(E56:GP57)+(C14-D14)^2/(0.4*C14)^2+(D15-C15)^2/(0.4*C15)^2+ (C19-D19)^2/(C19*0.4)^2)","v":0.72870916592558377}]

{"sheet":"lookuparray","index":3,"n_rows":19,"n_cols":17,"rows_kept":19,"cut":false,"hidden":true,"merged":[]}
["Age","Age","Age","Vmax","Km","Vd","Maintenance Dose Range","Reference",null,null,"Salt","Sex","Dialysis","Km (mg/L)",null,"Fitting Type"]
["0.5 to < 1",0.5,0.99,14,6.6,1,"?","?",null,"Capsule",0.92,"Male","No",1,null,1,"Km Vmax"]
["1 to < 4",0.5,3.9,14,6.6,0.65,"?","Clinical Pharmacokinetics John E Murphy 2005",null,"Injection",0.92,"Female","Yes",2,null,2,"Km Vax Vd"]
["4 to < 7",4,6.9,10.9,6.8,0.65,"4-10","Clinical Pharmacokinetics John E Murphy 2005",null,"Suspension",1,null,null,3]
["7 to < 10",7,9.9,10.1,6.5,0.65,"4-10","Clinical Pharmacokinetics John E Murphy 2005",null,"Tablet",1,null,null,4]
["10 to < 18",10,17.899999999999999,8.3000000000000007,5.7,0.65,"4-10","Clinical Pharmacokinetics John E Murphy 2005",null,null,null,null,null,4.3]
["18 to 59",18,59,7,4.3,0.65,"4-7","Clinical Pharmacokinetics John E Murphy 2005",null,null,null,null,null,5]
["> 59",59.1,120,7,5.8,0.65,"4-7","Clinical Pharmacokinetics John E Murphy 2005",null,null,null,null,null,5.8]
[null,null,null,null,null,null,null,null,null,null,null,null,null,6]
[null,null,null,null,null,null,null,null,null,null,null,null,null,7]
["Age","Age","Age","Vmax","Km","SD Vmax","CV Vax","SD Km","CV Km",null,null,null,null,8]
["0.5 to < 1",0.5,3.9,14,6.6,4.2,{"$f":"F12/D12","v":0.3},4.2,{"$f":"H12/E12","v":0.63636363636363646},null,null,null,null,9]
["1 to < 4",1,3.9,14,6.6,4.2,{"$f":"F13/D13","v":0.3},4.2,{"$f":"H13/E13","v":0.63636363636363646},null,null,null,null,10]
["4 to < 7",4,6.9,10.9,6.8,3,0.27522935779816515,3.5,0.51470588235294124,null,null,null,null,11]
["7 to < 10",7,9.9,10.1,6.5,2.6,0.25742574257425743,3,0.46153846153846156,null,null,null,null,12]
["10 to < 18",10,17.899999999999999,8.3000000000000007,5.7,2.8,0.33734939759036142,2.7,0.47368421052631582,null,null,null,null,13]
["18 to 59",18,59,7,4.3,3,0.42857142857142855,3.5,0.81395348837209303,null,null,null,null,14]
["> 59",59.1,120,7,5.8,3,0.42857142857142855,2.2999999999999998,0.39655172413793099,null,null,null,null,15]
[null,null,null,null,null,null,null,null,null,null,null,null,null,16]