| Enter Age (years) |
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| Enter Height in
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| Enter Actual Weight in |
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| Select Sex |
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| Enter Most Recent Serum Creatinine (mg/dl) |
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Enter Previous Serum Creatinine
(mg/dl)
Use the same value twice if renal function is stable. |
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| Enter time between serum
creatinines (hours). Use 24 if renal function is stable.
Creatinines should be >
1 T1/2 apart to
accurately determine creatinine clearance when renal function is changing. |
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The factors below are known to
clinically impact the kinetics of lithium. When more than one
factor is present the values are multiplied to obtain a final result.
If you wish to be conservative when multiple drug
interactions are present select the drug with the
greatest impact.
Other
significant interactions:
Decease clearance: Low salt diet, volume depletion,
hypothyroidism (untreated); Increase clearance: caffeine 300 mg increase clearance
26% for 4 hours, theophylline, sodium loading. |
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| Concurrent
hydrochlorthiazide (clearance decreased 50%) |
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| Concurrent Indomethacin,
150 mg per day or greater (clearance decrease 30%) |
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| Concurrent angiotensin
converting enzyme inhibitor (clearance decrease 50%) |
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| Select Dosage Form |
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| Select Drug |
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| |
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| Calculated Lean Body Weight (kg) |
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| Calculated Drug Dosing Weight (kg) |
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| Calculated Creatinine Clearance (ml/min) |
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| Calculated T1/2 for CREATININE (hours) |
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| Calculated Drug K (hours-1) |
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| Calculated Drug T1/2 (hours) |
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| Calculated Drug Vd (liters) |
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| Calculated Drug Clearance (liters/hour) |
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Calculated Daily Dose (mg)
For average level
of 0.8 mEq/Liter based on Dosing Weight |
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| Enter Rounded Dose (mg) |
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| Select Dosage Interval |
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Calculated Peak
(mEq/Liter)
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| Calculated Trough (mEq/Liter) |
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Calculated Average level
(mEq/Liter)
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Calculated Level
12
hours post-dose (mEq/Liter)
Chronic Therapy
Lithium 0.6-0.8 mEq /Liter
Acute Mania
Lithium 0.8-1.2 mEq/Liter
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| Serum level analysis:
Please complete the input boxes below if you have an actual
level and the time is was drawn.
These values along with the entered dosage history will be used to calculated the
patient's elimination rate constant (K). |
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Enter Actual Measured Steady
State Level mEq/liter.
Levels should be drawn 12 hours after the evening dose, as this is how therapeutic levels
were defined during clinical studies. Serum levels are recommended after 5 half-lives.
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| Enter Time Level Drawn FROM START OF PREVIOUS DOSE
(hours) |
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| K (hours-1) Fit (Fit from level, time of level,
and entered dosage history.) |
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| Thanks for using the program. If you
have any comments, suggestions or questions please contact the author. |
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