Pulse Dosing of Aminoglycosides & Vancomycin Dosing For Adults

Marshall Pierce, PharmD

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Use the tab key to navigate the form. Required data entry fields are teal in color.
Enter Age (years)
Enter Height in
Enter Actual Weight in
Select Sex
Enter Most Recent Serum Creatinine (mg/dl)
Enter Previous Serum Creatinine (mg/dl)
Use the same value twice if renal function is stable.

Enter time between serum creatinines (hours). Use 24 if renal function is stable. Creatinines should be > 1 T1/2 apart to accurately determine creatinine clearance when renal function is changing.
Select Drug
Enter Infusion Period (hours):
Aminoglycosides( 0.5-1 hours)
Vancomycin 2 hours (500 mg/hour)
Calculated Lean Body Weight (kg)
Calculated Drug Dosing Weight (kg)

Body Surface Area (Meters Squared)
DuBois & DuBois Formula

Calculated Weight Used In Creatinine Clearance Calculation
Calculated Creatinine Clearance (ml/min)
Calculated T1/2 for CREATININE (hours)
Calculated Drug K (hours-1)
Calculated Drug T1/2 (hours)
Calculated Drug Vd (liters)
Calculated Dose (mg)
Gentamicin/Tobramycin Pulse 5 mg/kg * Dosing Weight
Amikacin Pulse 15 mg/kg * Dosing Weight
Vancomycin 15 mg/kg * Actual Weight
Enter Rounded Dose (mg)
Calculated Dosing Interval (hours)

Enter Dosage Interval (hours)

Calculated Peak (mcg/ml)
Normal for Pulse Dosing
  Amikacin ~ 50-60 mcg/ml
  Gentamicin/Tobramycin ~ 18-20 mcg/ml
Maximum for Traditional Dosing :
  Amikacin ~30 mcg/ml
  Gentamicin/Tobramycin  10 mcg/ml  
      Pneumonia 8-10 mcg/ml  
      Sepsis 6-8 mcg/ml  
      UTI 4-5 mcg/ml  
      Endocarditis 4-5 mcg/ml  

Calculated Trough (mcg/ml)
Maximum for Pulse Dosing:
  Amikacin 0.9 mcg/ml
  Gentamicin/Tobramycin  0.3 mcg/ml

Please complete the input boxes below if you have an actual level and the time is was drawn. These values along with the entered dose and frequency will be used to calculated the patient's elimination rate constant (K).
Enter Actual Measured Level mcg/ml
Pulse Dose Levels are recommended to be drawn 14.5 hours from the start of the previous dose. True troughs should not be used with pulse dosing.  
Enter Time Level Drawn FROM START OF PREVIOUS DOSE (hours)
K (hours-1) Fit (Fit from level, time of level,  and entered dose and frequency.)
Thanks for using the program. If you have any comments, suggestions or questions please contact the author.


Copyright Marshall A. Pierce, all rights reserved, no warranties expressed or implied.