| Enter Age (years) |
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| Enter Height in
|
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| Enter Actual Weight in |
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| Select Sex |
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| Enter Most Recent Serum Creatinine (mg/dl) |
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Enter Previous Serum Creatinine
(mg/dl)
Use the same value twice if renal function is stable. |
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| Enter time between serum
creatinines (hours). Use 24 if renal function is stable.
Creatinines should be >
1 T1/2 apart to
accurately determine creatinine clearance when renal function is changing. |
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The factors below are known to clinically impact
the kinetics of digoxin. When more than one factor is
present the values are multiplied to obtain a final result. If you wish to
be conservative when multiple drug interactions are
present select the drug with the greatest impact.
Other
significant drug interactions:
Give
digoxin 1 or more hours before or two or more hours after: antacids
(absorption decreased 30%), cholestyramine/colestipol (absorption decreased 30%),
and kaolin-pectin (absorption decreased 60%).
Erythromycin and tetracycline therapy increase absorption
by altering bowel flora, requires increased monitoring.
|
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Congestive Heart Failure?
Clearance reduced 60% |
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Concurrent Quinidine?
Clearance reduced 50%, Vd
reduced 30% |
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Concurrent Amiodarone?
Clearance reduced 50% |
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Concurrent Verapamil?
Clearance reduced 25% |
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Clinically Hyperthyroid?
Clearance and Vd increased
30% |
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Clinically Hypothyroid?
Clearance and Vd reduced 30% |
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| Select Dosage Form |
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| Select Drug |
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| |
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| Calculated Lean Body Weight (kg) |
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| Calculated Drug Dosing Weight (kg) |
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| Calculated Creatinine Clearance (ml/min) |
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| Calculated T1/2 for CREATININE (hours) |
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| Calculated Drug K (hours-1) |
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| Calculated Drug T1/2 (hours) |
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| Calculated Drug Vd (liters) |
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| Calculated Drug Clearance (liter/hour) |
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Calculated Loading Dose (mg)
For 1 ng/ml (mcg/liter)
based on Dosing Weight
Administer in three
divided doses of 50%, 25% and 25% of total calculated dose with 6 hours
between each dose. Assumes no drug on board.
|
|
Calculated Daily Dose (mg)
For average level of
1 ng/ml (mcg/liter) based on Dosing Weight |
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| Enter Rounded Dose (mg) |
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| Select Dosage Interval |
|
|
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Calculated
Peak (ng/ml, mcg/liter)
Atrial Fibrillation
Digoxin < 2.5 ng/ml (mcg/liter)
Congestive
Heart Failure :
Digoxin < 1.5 ng/ml
(mcg/liter)
|
|
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Calculated
Trough (ng/ml, mcg/liter)
Usual Goal
for Atrial Fibrillation
Digoxin 1.5-2 ng/ml (mcg/liter)
Usual
Goal for Congestive Heart Failure :
Digoxin 0.8-1.2 ng/ml (mcg/liter)
|
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| Serum level analysis:
Please complete the input boxes below if you have an actual
level and the time is was drawn.
These values along with the entered dosage history will be used to calculated the
patient's elimination rate constant (K). |
|
Enter Actual
Measured Steady State Level ng/ml or mcg/l
True troughs are
suggested as dosage predictions will be more
accurate. Levels should be drawn at least 6 hours after an IV dose and 8 hours after an oral dose. Serum
levels are recommended after 2 and 5 half-lives.
|
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| Enter Time Level Drawn FROM START OF PREVIOUS DOSE
(hours) |
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| K (hours-1) Fit (Fit from level, time of level,
and entered dosage history.) |
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| Thanks for using the program. If you
have any comments, suggestions or questions please contact the author. |
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