| Enter Age (years) |
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| Enter Height in
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| Enter Actual Weight in |
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| Select Sex |
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| Enter Most Recent Serum Creatinine (mg/dl) |
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Enter Previous Serum Creatinine
(mg/dl)
(Use the same value twice is if renal function is stable) |
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| Enter time between serum
creatinines (hours). Use 24 if renal function is stable.
Creatinines should be >
1 T1/2 apart to
accurately determine creatinine clearance when renal function is changing. |
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Select Drug |
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Enter Infusion Period (hours):
Aminoglycosides( 0.5-1 hours)
Vancomycin 2 hours (1000 mg/hour) |
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| Calculated Lean Body Weight (kg) |
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| Calculated Drug Dosing Weight (kg) |
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Body Surface Area (Meters Squared)
DuBois & DuBois Formula |
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| Calculated Weight Used In Creatinine Clearance
Calculation |
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Calculated Creatinine Clearance (ml/min)
Pulse
Dosing is the preferred method of Aminoglycoside Dosing when Clcr
is > 30 ml/min or elimination rate constant of
aminoglycosides is > 0.08784
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| Calculated T1/2 for CREATININE (hours) |
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Calculated Drug K (hours-1)
Pulse Dosing is the preferred method of
Aminoglycoside Dosing when Clcr is > 30 ml/min or
elimination rate constant of aminoglycosides is >
0.08784 |
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| Calculated Drug T1/2 (hours) |
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| Calculated Drug Vd (liters) |
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| Calculated Drug Vd (liters/dosing weight
(kg)) |
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Calculated Loading Dose (mg)
Gent/Tobramycin ~ 2 mg/kg
for a level of 8
mcg/ml
Amikacin ~ 7.5 mg/kg for a level of 30 mcg/ml
Vancomycin ~ 25
mg/kg for a level of 40 mcg/ml (3 grams maximum dose is recommended) |
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Calculated Dose (mg)
Gentimicin/Tobramycin 1.5 mg/kg * Dosing Weight
Amikacin 7.5 mg/kg * Dosing Weight
Vancomycin 15 mg/kg * Actual Weight |
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| Enter Rounded Dose (mg) |
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| Calculated Dosing Interval (hours) |
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| Enter Dosage Interval (hours) |
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Calculated Peak (mcg/ml)
Maximum for Traditional Dosing:
Amikacin 30 mcg/ml
Gentamicin/Tobramycin 10 mcg/ml
Pneumonia 8-10 mcg/ml
Sepsis 6-8 mcg/ml
UTI 4-5 mcg/ml
Endocarditis 4-5 mcg/ml
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Calculated Trough (mcg/ml)
Maximum for Traditional Dosing:
Non Dialysis Patient
Amikacin 5 mcg/ml
Gentamicin/Tobramycin 1.5 mcg/ml
Dialysis Patient
Amikacin 10 mcg/ml
Gentamicin/Tobramycin 3 mcg/ml
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Area
Under the Curve each 24 hours [(mg*h/ (L)]
Amikacin:
Pulse Dosing 15 mg/kg Maximum AUC 380 mg*h/L per day
Gentamicin/Tobramycin:
Pulse Dosing 5 mg/kg Maximum AUC 127 mg*h/L per day
Pulse Dosing 7 mg/kg Maximum AUC 172 mg*h/L per day
Vancomycin AUC of 400-600 mg*h/L
per day
Monitor serum
levels with a peak and trough after the same dose.
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| Please complete the input boxes below if you
have steady state levels and the time they were drawn.
These values along with the entered dose, frequency, and infusion
period will be used to find the patient's elimination rate
constant (K) and Volume of Distribution (Vd). |
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| Enter Measured Peak (mcg/ml) |
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| Enter Time
Peak Drawn From END of Infusion (hours) |
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| Enter Measured Trough (mcg/ml) |
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| Enter Time Measured Trough Drawn Before START of Infusion (hours) |
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Fit K (hours-1)
Using Peak, Trough, Dosage Interval, Infusion Period, and Time of Levels. |
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Fit Vd (liters)
Using Peak, Dose, Dosage Interval, Infusion Period, Time of Peak,
and Calculated K. |
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| Thanks for using the program. If you
have any comments or questions please contact the author. |
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