Bayesian Pharmacokinetic Drug Dosing For Vancomycin and Aminoglycosides In Adults,
With Serum Level Analysis of Steady-State & Non-Steady-State Levels,
Using A Simplex Non-Linear Data Fitting Algorithm

Marshall Pierce PharmD

Create and enter patient unique HIPPA compliant identifier
Enter Last Name
Enter First Name
Enter Age (Years)
Enter Height
Select Height Units: Inches Centimeters
Enter Actual Weight
Select Weight Units: Kg Lbs
Select Biologic Gender: Female Male
Enter Most Recent Serum Creatinine (mg/dL)
Enter Time of Most Recent Serum Creatinine
(YYYY/MM/DD HH:MM Military Time)
Enter Previous Serum Creatinine (mg/dL)
Enter Time of Previous Serum Creatinine
(YYYY/MM/DD HH:MM Military Time)
Calculated Time Between Serum Creatinines (Hours)
Select Drug: Vancomycin Gentamicin/Tobramycin Amikacin
Enter Infusion Period (hours)
Calculated Lean Body Weight (Kg)
Calculated Dosing Weight (Kg)
Calculated Body Surface Area (Meters Squared)
Dubois & Dubois Formula
Calculated Creatinine Clearance Renal Function(Adults (ml/min),
Pediatric (ml/min/1.73 Meter Squared))
Calculated CREATININE Half-Life (Hours) Bayesian/Non-Bayesian Fit Values
Calculated Elimination Rate (1/Hours)
Calculated Drug Half-Life (Hours)
Calculated Volume of Distribution (Liters)
Calculated Volume of Distribution (L/kg)
Calculated Loading Dose (mg)
Gent/Tobramcyin ~ 2 mg/kg for level of 8 mcg/ml
Amikacin ~ 9 mg/kg for level of 30 mcg/ml
Vancomycin ~ 20 mg/kg for level of 30 mcg/ml
Calculated Maintenance Dose (mg)
Gent/Tobramcyin ~ 1.5 mg/kg
Amikacin ~ 7.5 mg/kg
Vancomycin ~ 15 mg/kg
Enter Rounded Dose (mg)
Calculated Dosing Interval (Hours)
Enter Rounded Dosing Interval (Hours) Bayesian/Non-Bayesian Calculated Values
Calculated Peak Steady State (mcg/ml)
Calculated Trough Steady State (mcg/ml)
Calculated Steady State AUC per 24 Hours (mg*hour/L per 24 hours)
Bayesian/Non-Bayesian Sum of Square of Errors for Data Fitting
Enter the Number of levels for Data Fitting
Enter the Number of Doses for Data Fitting
Fit Serum Level Data: Yes No
Bayesian Fitting: Yes No
Fitting Type: Fit Clearance & Vd Fit Clearance
Adjust Dose After Fitting Data:
Select Yes to lock the current data fitting.
Yes No


Serum Level, Dosing History, & Data Fitting Instructions:
Enter doses and serum levels, up to 14 of either, in chronological order down the page, oldest to most recent. Only enter the levels you want to analyze. Do not skip cells. A peak and trough are suggested to maximize the accuary of the data fitting and dosage predictions. If you only have a trough it is best to only fit the clearance. Run the data fitting several times in a row to identify the fitting with the lowest Sum of Square of Errors. Then Select "Yes" for "Adjust Dose After Fitting", "No" for "Fit Serum Levels", and adjust the dose/interval to obtain desired levels or AUC under the Bayesian/Non-Bayesian Calculated Values Column. The coefficient of variation (CV) of serum levels is much smaller than the CV of the Vd and CL so serum levels have the greatest impact on the Bayesian data fitting. A non-bayesian analysis is available for comparison.
Additional functionality is in development.
No Warrenties are expressed or implied.


Input Level (mg/ml)
Before The First Dose,
Enter 0 if no drug is on board.
Do not leave the cell blank.		 Input Time of Level
YYYY/MM/DD HH:MM
Military Time
Enter the time of the first dose
if no drug is on board
Dose (mg) Time of Dose
YYYY/MM/DD HH:MM
Miliary Time		 Expected Level
(mcg/ml)		 Measured Level
(mcg/ml)		 Time of Level
YYYY/MM/DD HH:MM
Military Time		 Serum Creatinine
(mg/dL)		 Time of Creatinine
YYYY/MM/DD HH:MM
Military Time		  
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